RESUMO
BACKGROUND AND AIMS: The diabetes eating problem survey-revised (DEPS-R) questionnaire is a specific and valuable tool for assessing disturbed eating behavior in type 1 diabetes mellitus. The literature suggests an association between a higher DEPS-R score and worse metabolic control; however, these figures have not been described in patients from Latin America. METHODS: We evaluated 58 patients with type 1 diabetes mellitus from a Brazilian outpatient clinic using the DEPS-R questionnaire. RESULTS: Overall, 23 participants with a high risk for high eating disorder behaviors exhibited significantly increased hemoglobin A1c levels compared with 35 patients with a DEPS-R score <20. CONCLUSIONS: Our data support that the presence of a DEPS-R score >20 negatively affects the metabolic control of patients with type 1 diabetes mellitus in Brazil.
Assuntos
Diabetes Mellitus Tipo 1 , Transtornos da Alimentação e da Ingestão de Alimentos , Brasil , Hemoglobinas Glicadas , Controle Glicêmico , Humanos , Inquéritos e QuestionáriosRESUMO
It has been well documented that there is an increased prevalence of standard cardiovascular (CV) risk factors in association with diabetes and with diabetes-related abnormalities. Hyperglycemia, in particular, also plays an important role. Heart failure (HF) has become a frequent manifestation of cardiovascular disease (CVD) among individuals with diabetes mellitus. Epidemiological studies suggest that the effect of hyperglycemia on HF risk is independent of other known risk factors. Analysis of datasets from populations including individuals with dysglycemia suggests the pathogenic role of hyperglycemia on left ventricular function and on the natural history of HF. Despite substantial epidemiological evidence of the relationship between diabetes and HF, data from available interventional trials assessing the effect of a glucose-lowering strategy on CV outcomes are limited. To provide some insight into these issues, we describe in this review the recent important data to understand the natural course of CV disease in diabetic individuals and the role of hyperglycemia at different times in the progression of HF.
Assuntos
Cardiomiopatias Diabéticas , Insuficiência Cardíaca/etiologia , Hiperglicemia/complicações , Disfunção Ventricular Esquerda/etiologia , Animais , Cardiomiopatias Diabéticas/fisiopatologia , Modelos Animais de Doenças , Progressão da Doença , Ecocardiografia Doppler , Estudos Epidemiológicos , Insuficiência Cardíaca/fisiopatologia , Humanos , Hiperglicemia/fisiopatologia , Fatores de Risco , Disfunção Ventricular Esquerda/fisiopatologiaRESUMO
It has been well documented that there is an increased prevalence of standard cardiovascular (CV) risk factors in association with diabetes and with diabetes-related abnormalities. Hyperglycemia, in particular, also plays an important role. Heart failure (HF) has become a frequent manifestation of cardiovascular disease (CVD) among individuals with diabetes mellitus. Epidemiological studies suggest that the effect of hyperglycemia on HF risk is independent of other known risk factors. Analysis of datasets from populations including individuals with dysglycemia suggests the pathogenic role of hyperglycemia on left ventricular function and on the natural history of HF. Despite substantial epidemiological evidence of the relationship between diabetes and HF, data from available interventional trials assessing the effect of a glucose-lowering strategy on CV outcomes are limited. To provide some insight into these issues, we describe in this review the recent important data to understand the natural course of CV disease in diabetic individuals and the role of hyperglycemia at different times in the progression of HF.
Já foi bem documentado um aumento da prevalência dos fatores de risco cardiovascular convencional em portadores de diabetes melito e em pessoas com as anormalidades relacionadas ao diabetes. A hiperglicemia, particularmente, teria um papel crítico. A insuficiência cardíaca (IC) tem se tornado uma manifestação frequente da doença cardiovascular em indivíduos com diabetes. Estudos epidemiológicos sugerem que o efeito da hiperglicemia no risco para IC é independente dos outros fatores de risco. A análise dos dados de populações que incluem indivíduos com disglicemia sugere um papel patogênico da hiperglicemia na função do ventrículo esquerdo na história natural da IC. A despeito de evidências epidemiológicas na relação entre diabetes e IC, os dados disponíveis de estudos clínicos de intervenção para avaliar o efeito da estratégia de redução da glicose sobre os desfechos cardiovasculares ainda são limitados. Para trazer alguma compreensão nesse tópico, descrevemos nesta revisão os dados recentes e importantes para entender a história natural da doença cardiovascular em indivíduos com diabetes e o papel da hiperglicemia em diferentes períodos na progressão da doença.
